Cardiovascular and Respiratory Health Screening
Your heart and lung health is shaped by both genetics and lifestyle. MyHeritage DNA 360° reveals genetic risks that can help you and your healthcare provider plan ahead.
What your DNA results can help you do
Lifestyle and routine health measurements reveal part of the picture of your heart and lung health. Your DNA can uncover risks that might otherwise remain hidden.
Look beyond the usual risk factors
Learn whether your DNA is associated with an increased risk for common cardiovascular and respiratory conditions, including coronary artery disease, atrial fibrillation, high blood pressure, stroke, and asthma.
Identify conditions that can run in families
Discover genetic variants linked to inherited conditions affecting the heart, blood vessels, cholesterol levels, and lungs. Some may be relevant to your relatives as well.
Make more informed decisions
Share relevant findings with your healthcare provider to discuss whether earlier screening, closer monitoring, lifestyle changes, or other preventive measures may be appropriate for you.
Explore cardiovascular and respiratory reports
Reports include:
Heart disease
Coronary artery disease
Atrial fibrillation
High blood pressure
Stroke
Asthma
Familial hypercholesterolemia
Hypertrophic cardiomyopathy
Dilated cardiomyopathy
Long QT syndrome
Brugada syndrome
Marfan syndrome
Loeys-Dietz syndrome
Aortic Aneurysm
A bulge or weakening in the wall of the aorta, the body's main artery. It often causes no symptoms but can tear or rupture, which is life-threatening.
ApoB
Apolipoprotein B (ApoB) is the main structural protein on LDL, VLDL, and other plaque-forming cholesterol particles, with one ApoB molecule on each particle. Because of this, ApoB reflects the total number of these particles in the blood and is a strong marker of cardiovascular risk.
Arrhythmogenic Right Ventricular Cardiomyopathy
(PKP2, DSP, DSC2, DSG2, TMEM43)
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic disorder of the heart muscle, predominantly affecting the right ventricle. It is characterized by the replacement of myocardial tissue with fibrous and fatty tissue, leading to arrhythmias and an increased risk of sudden cardiac death (SCD).
Asthma
Asthma is a chronic condition of the airway and lungs in which exposure to certain triggers causes the airways to become inflamed, swollen, and narrowed. This constriction restricts the flow of air into and out of the lungs, leading to episodes of wheezing, shortness of breath, chest tightness, and coughing.
Calmodulinopathy
(CALM1, CALM2, CALM3)
Calmodulinopathy is a rare arrhythmia syndrome caused by mutations in any of the three calmodulin genes (CALM1, CALM2, CALM3), leading to life-threatening cardiac arrhythmias, particularly in young individuals. The phenotype overlaps with both long QT Syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT).
Coronary Artery Disease
Coronary artery disease (CAD), also known as coronary heart disease (CHD), is the most common type of heart disease. It develops when plaque — a buildup of cholesterol, fat, calcium, and other substances — accumulates inside the coronary arteries, narrowing the blood vessels that deliver oxygen-rich blood to the heart muscle.
Ehlers-Danlos Syndrome, Vascular Type
(COL3A1)
Vascular Ehlers-Danlos Syndrome (vEDS) is a rare connective tissue disorder characterized by arterial, intestinal, and uterine fragility, leading to a heightened risk of spontaneous vascular or visceral rupture. It is primarily caused by mutations in the COL3A1 gene, which encodes a type of collagen, crucial for blood vessel walls and hollow organs.
HDL Cholesterol
High-density lipoprotein (HDL) carries cholesterol from the arteries and tissues back to the liver, which removes it from the body. It is often called “good” cholesterol because higher levels are generally linked to a lower risk of heart disease.
Heart disease
Heart disease, also known as cardiovascular disease, generally describes conditions caused by narrowing or blockage of the blood vessels that supply blood to the heart itself. This is the major reason that people have heart attacks.
High blood pressure
High blood pressure, also called hypertension, refers to elevated blood pressure over a long period of time. Blood pressure is the force your blood exerts on your arteries as it moves through them from your heart to other parts of your body.
LDL Particle Number (LDL-P)
A count of the LDL particles in the blood, which can differ from the amount of cholesterol they carry. A high particle number is linked to greater cardiovascular risk even when LDL cholesterol looks normal.
Lipoprotein(a)
Lipoprotein(a), or Lp(a), is an LDL-like particle made in the liver, with an extra protein called apolipoprotein(a) attached to its surface. Levels are largely set by genetics and change little over a lifetime, and high levels are linked to a higher risk of heart disease, stroke, and narrowing of the aortic valve.
Loeys-Dietz Syndrome
(TGFBR1, TGFBR2, SMAD3)
Loeys-Dietz Syndrome (LDS) is a genetic connective tissue disorder characterized by arterial aneurysms, arterial tortuosity, and various craniofacial and skeletal manifestations (e.g. hypertelorism, bifid/split uvula, cleft palate, premature fusion of the skull, and cervical spine deformity). It is commonly caused by mutations in TGFBR1 and TGFBR2 genes (also SMAD3), with autosomal dominant inheritance with variable penetrance.
Long QT Syndrome Type 1
(KCNQ1)
Long QT Syndrome (LQTS) is a cardiac disorder characterized by a prolonged QT interval on the electrocardiogram (ECG), which can lead to life-threatening arrhythmias. LQTS type 1 (LQT1) accounts for 35-40% percent of LQTS and is caused by loss-of-function variants in the KCNQ1 gene.
Marfan Syndrome
(FBN1)
Marfan syndrome (MFS) is one of the most common inherited disorders of connective tissue. It is an inherited disorder that commonly causes ocular, cardiovascular and musculoskeletal abnormalities, but can also affect the skin, lung and CNS.
Peripheral Artery Disease
A condition where narrowed arteries reduce blood flow to limbs, prevalent in older adults, leading to pain and mobility issues.
Thoracic Aortic Disease
(ACTA2, MYH11)
Heritable thoracic aortic disease (HTAD) is a genetic condition characterized by the enlargement of the thoracic aorta, which can lead to dissection or rupture. This condition can result from mutations in the ACTA2 and MYH11 genes, and often follows an autosomal dominant inheritance pattern.
VLDL Cholesterol
VLDL particles are made by the liver to carry triglycerides, along with some cholesterol, through the blood. High levels are linked to elevated triglycerides and a higher risk of heart disease.
Aortic Stenosis
A narrowing of the aortic valve that restricts blood flow from the heart to the rest of the body. It tends to worsen with age and can cause chest pain, breathlessness, and fainting.
Artery Hardening
The blood vessel walls become thick and stiff. This is called artery hardening (arteriosclerosis).
Atrial fibrillation
Atrial fibrillation (AFib) is the most common form of heart arrhythmia. An arrhythmia is when the heart beats too fast, too slow, or in an irregular pattern.
Catecholaminergic Polymorphic Ventricular Tachycardia
(RYR2, CASQ2, TRDN)
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a genetic disorder that predisposes individuals to potentially life-threatening arrhythmias, particularly during physical activity or emotional stress. It is characterized by bidirectional or polymorphic ventricular tachycardia in the presence of a structurally normal heart.
Cold Hands and Feet (Raynaud’s)
Raynaud's is a rare disorder of the blood vessels. It causes the blood vessels to narrow when you are cold or feeling stressed, and usually affects the fingers and toes.
Dilated Cardiomyopathy
(TNNT2, LMNA, FLNC, TTN, BAG3, DES, RBM20, TNNC1, PLN)
Dilated cardiomyopathy (DCM) is a disorder characterized by the enlargement and impaired contraction of the heart's ventricles, leading to heart failure and arrhythmias. Familial DCM is caused by pathogenic mutations in genes such as BAG3, DES, FLNC, LMNA, PLN, RBM20, TNNC1, TNNT2, and TTN.
Familial Hypercholesterolemia
(APOB, PCSK9, LDLR)
Familial Hypercholesterolemia (FH) is the most common autosomal dominant genetic disease. It is characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C) levels and a propensity to early-onset atherosclerotic cardiovascular disease.
Hereditary TTR (transthyretin) amyloidosis
(TTR)
Hereditary transthyretin (TTR) amyloidosis is a rare, inherited condition caused by mutations in the TTR gene. It is characterized by the deposition of amyloid fibrils composed of misfolded transthyretin (TTR) protein in various organs.
Hypertrophic Cardiomyopathy
(MYH7, MYBPC3, TNNI3, TPM1, MYL3, ACTC1, PRKAG2, MYL2)
Hypertrophic Cardiomyopathy (HCM) is a genetic disorder characterized by the abnormal thickening of the heart muscle. This thickening can lead to obstruction of blood flow, diastolic dysfunction, and an increased risk of arrhythmias.
LDL Cholesterol
Low-density lipoprotein (LDL) is the main carrier of cholesterol in the blood, delivering it to cells throughout the body. It is often called “bad” cholesterol because high levels can build up in artery walls as plaque and raise the risk of heart disease and stroke.
LDL Particle Size
Research suggests that small LDL more easily goes into blood vessel walls, where it deposits as plaque, while larger particles tend to bounce off blood vessel walls. That's why small LDL may be worse, even though it carries less cholesterol than the larger particles.
Long QT Syndrome 3; Brugada Syndrome
(SCN5A)
Mutations in the SCN5A gene are most commonly associated with long QT syndrome and/or Brugada syndrome. Long QT Syndrome (LQTS) is a cardiac disorder characterized by a prolonged QT interval on the electrocardiogram (ECG), which can lead to life-threatening arrhythmias.
Long QT Syndrome Type 2
(KCNH2)
Long QT Syndrome (LQTS) is a cardiac disorder characterized by a prolonged QT interval on the electrocardiogram (ECG), which can lead to life-threatening arrhythmias. LQTS type 2 (LQT2) accounts for 25 - 40% of cases of congenital LQTS and is caused by pathogenic mutations in the KCNH2 gene.
Low Blood Pressure
Blood pressure is a measurement of how hard your blood is pushing on the artery walls, and it drops when blood vessels widen or the heart pumps slower. Low blood pressure can lead to dizziness and fainting, but is generally manageable.
Mitral Valve Prolapse
A condition in which the flaps of the mitral valve bulge back into the heart's upper chamber with each beat. Most people have no symptoms, but some have palpitations or a leaking valve.
Stroke
A stroke occurs when blood flow to the brain is blocked or interrupted preventing oxygen from getting to brain cells. The most common type of stroke is called an ischemic stroke which is the result of blockage in the artery that takes blood to the brain.
Varicose Veins
Swollen, twisted veins, often in the legs, caused by weak or failing valves that allow blood to pool. Common symptoms include leg heaviness, aching, swelling, and cramping.
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